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KMID : 0438319960050010031
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Pusan Journal of Psychiatry
1996 Volume.5 No. 1 p.31 ~ p.49
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Effect of Radix Puerariae on Blood Alcohol and Acetaldehyde Concentration after Alcohol Intake in Normal Healthy Adults Endogenous Opioids.
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양재곤
박제민/김명정/김철민/김성곤
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Abstract
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The author investigated the effect of Radix puerariae on the metabolism of alcohol. Thirty seven normal healthy male adults were treated with either 12gm of crude powder of Radix puerariae or 6 gm of agar in two divided doses for 7 days in a
randomized,
double-blind design. On the first day, before the drugs were administered and the eighth day which is after the termination of the durg treatment, each subject was given an oral test dose of alcohol in an amount of 3 ml of 25%/㎏ ethanol and
blood
samples were taken at -5, 30, 60, 90, and 120 minutes after alcohol and acetaldehyde concentrations by means of gas chromatography. At each time of the blood sampling, vital signs, facial flushing, talkativeness, subjective mood, physical comfort
and
subjective craving for alcohol were measured. A few objective measurements of the mood state and basic hematologic, hepatic and renal function tests were done before and after the durg treatments. The results were as follows.
1. Blood alcohol concentration was significantly elevated at 30 through 90 minutes after ethanol intake in the radix puerariae group by 77 to 22% of magnitude. Blood alcohol concentration of the radix puerariae group was significantly higher as
compared to the control throughout the whole post-alcohol periods.
2. Acetaldehyde was significantly increased at 30 through 120 minutes after ethanol intake in the radix puerariae group by 47~14% magnitude. Acetaldehyde of the radix puerariae group was higher than the control at 30 and 90 minutes after ethanol
intake.
3. Radix puerariae augmented significantly the ethanol-induced enhancement of the subjective measures of mood and physical comfort and also increased the amount of the voluntary verbalizations.
4. Radix puerariae effected a small but significant reduction of the basal body temperature.
5. Radix puerariae blocked the ethanol-induced increase of pulse rate but did not exert any influence on blood pressure.
6. Radix puerariae did not lower alcohol craving before ethanol intake, but did enhance alcohol craving after ethanol intake.
7. No significant adverse effect of radix puerariae was observed.
From these results, it is suggested that radix puerariae contains substances inhibiting alcohol dehydrogenase and/or aldehyde dehydrogenase. The reduction of alcohol comsumption by radix puerariae may not be directly related with it's capacity to
increase blood alcohol and/or acetaldehyde concentration .
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